Active substance: Norfloxacin
If you have a heart condition, or if you have been told you have an unusual heartbeat. If you have a condition causing tired and weak muscles, called myasthenia gravis.
This is a genetic disorder which causes problems after eating foods such as fava beans. If you are taking any other medicines.
This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines. If you have ever had an allergic reaction to a medicine.
How to take norfloxacin Before you start taking the tablets, read the manufacturer's printed information leaflet from inside the pack.
Take norfloxacin exactly as your doctor tells you to. The usual dose is one 400 mg tablet, taken twice a day. Swallow the tablet with a drink of water. This is because your body absorbs less norfloxacin after a meal, which means the medicine is less effective.
Try to space out the doses over the day - so ideally, take a dose every 12 hours. Do not drink milk or take indigestion remedies or medicines containing iron or zinc such as multivitamin tablets during the two hours before you take norfloxacin, or during the two hours after you have taken a dose.For these reasons, before you start taking norfloxacin it is important that another quinolone antibiotic these are called ofloxacin, levofloxacin, ciprofloxacin, moxifloxacin, and nalidixic.
This is because these things interfere with the way norfloxacin is absorbed by your body, and stop it from working fully. As such, these drug interactions involving the fluoroquinolones appear to be drug specific rather than a class effect. The fluoroquinolones have also been shown to interfere with the metabolism of caffeine and the absorption of levothyroxine.
This might increase the risk of methotrexate toxic reactions. Current or past treatment with oral corticosteroids is associated with an increased risk of Achilles tendon rupture, especially in elderly patients who are also taking the fluoroquinolones.
Careful monitoring and supportive treatment, monitoring of renal and liver function, and maintaining adequate hydration is recommended by the manufacturer.
At the respective doses, mean peak serum and plasma concentrations of 0. The effective half-life of norfloxacin in serum and plasma is 3—4 hours.
Steady-state concentrations of norfloxacin will be attained within two days of dosing.
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