Active substance: Norfloxacin
Accordingly, patients are often misdiagnosed and receive ineffective treatment, resulting in poor quality of life. Category IV asymptomatic inflammatory prostatitis is accidentally discovered during a physical examination or office visit for other genitourinary disorders e.
The overall rate of adverse events in patients treated with fluoroquinolones is roughly similar to that seen in patients treated with other antibiotic classes.
Centers for Disease Control study found patients treated with fluoroquinolones experienced adverse events severe enough to lead to an emergency department visit more frequently than those treated with cephalosporins or macrolides, but less frequently than those treated with penicillins, clindamycin, sulfonamides, or vancomycin.
Among these, tendon problems and exacerbation of the symptoms of the neurological disorder myasthenia gravis are the subject of "black box" warnings in the United States. Younger people typically experience good recovery, but permanent disability is possible, and is more likely in older patients.
Simultaneous use of corticosteroids is present in almost one-third of quinolone-associated tendon rupture. Fluoroquinoline treatment is associated with risk that is similar to or less than that associated with broad spectrum cephalosporins.
Therefore, cyclosporine serum levels should be monitored and appropriate cyclosporine dosage adjustments made when these drugs are used concomitantly.
Medications Some quinolones exert an inhibitory effect on the cytochrome P-450 system, thereby reducing theophylline clearance and increasing theophylline blood levels.
Chronic pelvic pain in men workup.
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Chronic bacterial prostatitis: therapeutic experience with ciprofloxacin.
Outcome of antibiotic therapy with ciprofloxacin in chronic bacterial prostatitis. Ciprofloxacin in the treatment of chronic bacterial prostatitis: a prospective, non-comparative multicentre clinical trial with long-term follow-up.
The German Prostatitis Study Group. Int J Antimicrob Agents. Alexander RB.