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    Key inclusion criteria Male and female patients aged 16—70 years with a diagnosis of epilepsy with POS, and electroencephalography EEG and brain computerized tomography CT scan or magnetic resonance imaging MRI evaluation consistent with this diagnosis, were enrolled in the study.

    This study used the International Classification of Epileptic Seizures, 1981.

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    A stable dose of one or two marketed AEDs for at least 28 days was required prior to Baseline and during the Baseline Phase. Additional exclusion criteria included any history of conversion disorders or other nonepileptic ictal events.

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  • This finding thanks that gender appears to be a maximum independent variable in the development and evaluation of new pyramids for CUD, though few graves are published examining his role in treatment outcomes.
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  • Patients were also excluded from entering the study if they had an implanted vagus nerve stimulator, or had received benzodiazepines, phenobarbital, or primidone, or were regularly receiving neuroleptics, monoamine oxidase inhibitors, barbiturates, or narcotic analgesics within 28 days of study entry or during the Baseline Phase.

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    The main inborn errors of metabolism associated with epilepsy are reviewed in the Chap. The diagnosis of a genetic defect or an inborn error of metabolism often results in requests for a vast array of biochemical and molecular tests leading to an expensive workup.

    Although the diagnosis of epilepsy remains mainly clinical, Magnetic Resonance Imaging plays a crucial role in the detection of lesions that can cause epilepsy, with high impact on the diagnostic work-up as well as on therapeutic planning reviewed in Chap.

    Introduction

    Morphologic MR imaging is still the main technique for identifying lesions responsible for the epilepsy, providing images with high spatial resolu- tion, excellent soft-tissue contrast, and multiplanar view.

    Functional MR imaging is used for lateralizing language functions, and also for surgical planning predict- ing functional deficits following epilepsy surgery. Functional imaging and other methods have contributed to understanding how these seizures arise, as observed in patients with reflex seizures, which are provoked by specific external stimuli and that are important clues for investigating complex mechanisms of epileptogenesis Chap.

    Future technical progress will hopefully offer the opportunity for further investigating cortical areas and brain networks involved in cerebral functions and in epileptic discharges, thus contributing to the comprehension of mechanisms of epileptogenesis.

    A large section of the book is then dedicated to pathophysiological aspects of epilepsy and related conditions as well as the implications for the quest of new therapies. The adoption by ICD-10 finally provided a billable and reimbursable diagnosis for clinicians.

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    Although this is the rationale utilized by many of the clinical treatment studies, this has not been as well defined in the design and assessments in this setting.


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    The study made testimony of a combination outpatient maintenance medication variation and inpatient crossover design.

    Here we can take a lesson from tobacco-smoking cessation, as nicotine replacement therapy NRT is generally not sufficient as a monotherapy for most patients trying to achieve smoking cessation and the combination of other pharmacological agents eg, bupropion or varenicline with NRT in conjunction with counseling is now the gold standard of treatment Stead et al,; Mills et al,.

    Non-cannabinoid medications Noradrenergic Agents Some of the earliest work investigating medication as a potential treatment for CUD looked at antidepressants with noradrenergic reuptake inhibition.

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