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Thus, there is a substantial need for novel and clinically translatable pharmacologic targets in the field of pulmonary vascular biology.

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Our group and others have defined a role for myeloid-derived cells in the pathogenesis of PH 9, 10. Although the study of myeloid-derived cells in the pathobiology of vascular lung disease is still in its infancy, many groups have demonstrated strong evidence implicating leukocytes in the progression of PH 11, 12.


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Although, a vast number of immune effector cells are known to be involved in aberrant pulmonary vascular injury and repair 13 — 17, identification of a cellular intermediate orchestrating the response of these cells to inflammation and injury repair has remained elusive.

Such an intermediary would prove to be a potentially efficacious drug target. Previously, we have demonstrated the necessary role for chemokine receptors in the coordination of pathogenic vascular remodeling 18.

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Chemokine receptor C-X-C motif chemokine receptor CXCR 2 is an attractive focus for research in the field of vascular immunobiology 19, as it has been shown to be relevant to the pathogenesis of both PH 20 and pulmonary fibrosis 21.

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