Active substance: Clomiphene
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Therefore, the effectiveness of letrozole versus CC remains uncertain. The primary objective of this study was to test the hypothesis that letrozole as a primary OI agent will generate higher pregnancy rates than CC in anovulatory women with PCOS.
The purpose of the crossover design, was to test the efficacy of each drug as a secondary OI agent. Women not conceiving with the first drug were offered to crossover to the other one.Ovulation and Ovulation-Inducing Fertility Medications for releases two hormones: follicle stimulating hormone FSH and luteinizing hormone LH female reproductive system produces a mature.
It was sponsored by the University of Nottingham. All participants gave a written informed consent and the trial was monitored by the Sponsor.
All participants had proven patency of at least one fallopian tube and normal semen analysis of their male partners WHO, 1999.
We excluded patients who have received OI within 6 months and those with uncontrolled thyroid disease or hyperprolactinaemia. Interventions Letrozole and CC were prescribed by the senior investigator, SA orally daily for 5 days starting on Days 2—4 of a menstrual period or a progestogen-induced bleed medroxy-progesterone acetate 10 mg twice daily for 5 days.
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On day 11 or 12 of the menstrual cycle, ultrasound monitoring is conducted to determine if an ovarian follicle or follicles have developed. Also at this time, patients are asked to use an ovulation predictor kit to test their urine for a surge in LH luteinizing hormone indicating that eggs have matured and ovulation is imminent.
Natural intercourse or insemination is timed to ovulation. If ovulation has been assisted by an hCG injection, a form of the hormone progesterone is given via vaginal tablets or gel.
The progesterone hormone serves to support the endometrial uterine lining and prepare it for the fertilized egg. If the test is positive, a blood test will be performed to confirm results.
If ovulation doesn't occur during this initial clomiphene dosage, another course of provera will be prescribed and the dose of clomiphene increased until ovulation occurs. This is sometimes referred to as "superovulation. Starting clomiphene early in the cycle helps with the recruitment of more than one mature egg.
Typically, two clomiphene citrate 50-mg tablets are taken orally for 5 days, from cycle day 3 to cycle day 7. The ultrasound helps to determine how many mature eggs are forming within their follicles.
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