Active substance: Clomiphene
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There are many activities that go on fertility treatment with Clomid. Clomiphene is used to induce ovulation egg production in women who do not produce ova eggs but wish to become pregnant infertility.
Live-birth rate Only one trial, Elstein and Fawcett 1984, reported all pregnancy outcomes, including miscarriages and live births.
In this one trial, there was no significant difference between the groups in the odds of live birth per cycle OR 0.
Discussion In approaching this review, we theorized that tamoxifen's estrogenic effects on the endometrium and cervical mucus would result in higher pregnancy rates.
In this meta-analysis, both SERM were equally effective in inducing ovulation. The ovulation rates were high in both groups; however, pregnancy rates were much lower.
Despite the theoretical benefits of tamoxifen, this meta-analysis failed to find a significant benefit of tamoxifen over clomiphene for inducing pregnancy.
Although the odds of pregnancy were higher after ovulation with tamoxifen, this finding was not statistically significant. This meta-analysis is limited by the quality of the included papers. Others have expressed concerns with the use of the cycle as a unit of analysis in subfertility trials Vail and Gardener,, cross-over design use in subfertility trials Daya,, and combining parallel and cross-over trials Elbourne et al.
However, these methods continue to be commonly used in the fertility literature Elbourne et al.
In general, this meta-analysis of randomized controlled trials provides a fairly precise estimate of the effect of SERM on ovulation induction. The similarity in ovulation rates differs from the conclusions by Borenstein et al.
Other retrospective studies have concluded that the two agents act similarly Gerhard and Runnebaum, 1979; Weseley and Melnick, 1987. However, Gerhard and Runnebaum 1979 concluded that ovulation rates with tamoxifen did tend to be higher than those with clomiphene in women with oligomenorrhoea.
This analysis failed to demonstrate any difference in ovulation rates between clomiphene and tamoxifen.
No studies have addressed the use of adjuvant medications, such as metformin or hCG, with tamoxifen.
Clomid is usually started at 50 mg. If this dose does not produce eggs, then the dose can be increased to 100 mg.