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In 101 placebo-treated patients mean age 59 years and BMI 29. The incidence of AEs was higher in the tadalafil group 55. They enrolled 427 men who had been investigated in a 12-week, placebo-controlled, dose-finding study with once-daily tadalafil 2.

A total of 22 men 5. Thus, this long-term study showed that tadalafil 5 mg once daily is well tolerated during a treatment period of 1 year and that the drug maintains or even improves storage and voiding symptoms, but the cost-effectiveness of the long-term chronic use of tadalafil was not evaluated.

In, Oelke et al 54 evaluated for the first time tadalafil 5 mg and tamsulosin 0.

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Compared with placebo, there was a significant decrease in IPSS of 1. After 12 weeks, decrease in IPSS with tadalafil 2. Improvement in IIEF score was once more documented for tadalafil 4. The patient discontinuation rate due to AEs was 1.

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The unexpected outcome of this study was the significant improvement of uroflowmetry parameters. Qmax and Qave similarly increased with both tadalafil 2.

Patients were equally randomized into two treatment arms: once-daily tamsulosin 0. The study design included an urodynamic study based on the recommendations of the International Continence Society.


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