Active substance: Isotretinoin
+ free Accutane pill.
Patients at increased risk for early relapse included younger patients with acne of relatively recent onset, those with truncal acne, and women with polycystic ovary syndrome.
In our study, relapse rate had not any relation with patient's weight, age, and anatomical location of lesions.
Safety was assessed during the study by the reporting of adverse events. The most common side-effects in our study were mild cheilitis in 93 patients 66.
The observed side-effects were mild, and only 6 patients discontinued study medication because of severe adverse events.
Isotretinoin can cause variant side-effects; mucocutaneous side-effects are the most common, experienced by virtually all patients.
Epistaxis only seen in conventional group but in our study.
Elevated liver function test results, and increase in serum lipid profiles was mild, and usually returned to normal within 6-8 weeks, despite continuation of treatment.
The present study showed that low dose 20 mg daily isotretiinoin represents a well-tolerated and efficient alternative to the standard 0.
The only pitfall is it is longer than 10 months duration of treatment period. The low frequency of adverse side-effects in this study, suggest that most side effects of the drug, are dose dependent; and the most serious side effects of the drug can be reduced significantly by using lower doses.
Hence, we recommend this low dose therapy for treatment of moderate to severe scar prone acne. A large, prospective randomized comparative study is needed to establish the definitive response and tolerance of this protocol.
Footnotes Conflict of Interest: None declared.
Prevalence of facial acne vulgaris in late adolescence and in adults. Are there other acne treatments?
Isotretinoin capsules are usually only used for people whose acne doesn't improve with other treatments. But there are other options for some people with severe acne, for example, treatments that use lasers, and other light devices and chemical peels.
Why is isotretinoin no longer available as a gel?
Isotretinoin used to also come as a gel, known by the brand name Isotrex. In GSK stopped manufacturing Isotrex gel.
This medicine is no longer available in the UK. However there is a gel containing isotretinoin and erythromycin brand name Isotrexin.In only twenty patients, slight elevation of liver enzymes and serum lipids was detected. In no patient was the treatment discontinued due to the abnormality in laboratory values.
There are also other gels that contain tretinoin or adapalene. These work in a similar way to isotretinoin gel. Ask your specialist or a pharmacist for advice about suitable alternatives and the best treatment for your condition.
Will it affect my fertility? There's no firm evidence to suggest that taking isotretinoin capsules will reduce fertility in either men or women.
However, women are advised not to take isotretinoin capsules if they're pregnant or trying for a baby.